Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance.

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Postsynaptic Mad Signaling at the Drosophila Neuromuscular Junction

BACKGROUND Cell-to-cell communication at the synapse involves synaptic transmission as well as signaling mediated by growth factors, which provide developmental and plasticity cues. There is evidence that a retrograde, presynaptic transforming growth factor-beta (TGF-beta) signaling event regulates synapse development and function in Drosophila. RESULTS Here we show that a postsynaptic TGF-be...

متن کامل

Cytoplasmic actin in postsynaptic structures at the neuromuscular junction

We used an antibody prepared against Aplysia (mollusc) body-wall actin that specifically reacts with certain forms of cytoplasmic actin in mammalian cells to probe for the presence of actin at the neuromuscular junction. Immunocytochemical studies showed that actin or an actinlike molecule is concentrated at neuromuscular junctions of normal and denervated adult rat muscle fibers. Actin is pres...

متن کامل

Postsynaptic effect of i.v. anaesthetic agents at the neuromuscular junction.

The effects of sodium thiopentone 19-757 mumol/litre, sodium pentobarbitone 25-806 mumol/litre, propanidid 74-1186 mumol/litre, Althesin 55-220 mumol/litre, diazepam 17.6-140 mumol/litre and ketamine 1.8-116.8 mumol/litre on the time-course of miniature end-plate currents of the excised mouse diaphragm were investigated. The currents were detected by means of extracellular electrodes and record...

متن کامل

Postsynaptic chromatin is under neural control at the neuromuscular junction.

In adult skeletal muscle, the nicotinic acetylcholine receptor (AChR) specifically accumulates at the neuromuscular junction, to allow neurotransmission. This clustering is paralleled by a compartmentalization of AChR genes expression to subsynaptic nuclei, which acquire a unique gene expression program and a specific morphology in response to neural cues. Our results demonstrate that neural ag...

متن کامل

ColQ controls postsynaptic differentiation at the neuromuscular junction.

CollagenQ (ColQ) plays an important structural role at vertebrate neuromuscular junctions (NMJs) by anchoring and accumulating acetylcholinesterase (AChE) in the extracellular matrix (ECM). Moreover, ColQ interacts with perlecan/dystroglycan and the muscle-specific receptor tyrosine kinase (MuSK), key molecules in the NMJ formation. MuSK promotes acetylcholine receptor (AChR) clustering in a pr...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1979

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.76.4.2062